Immunoreactive gastrin components in human serum

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Immunoreactive gastrin components in human serum.

The apparent molecular size and charge of immunoreactive gastrin components were studied in sera from patients with pernicious anaemia or gastrinomas (the Zollinger-Ellison syndrome) by Sephadex gel filtration and aminoethylcellulose chromatography. The following serum components were distinguished: (1) a monophasic component I similar in size to proinsulin which was converted into ;little' gas...

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Increased serum immunoreactive gastrin levels in idiopathic hypertrophic pyloric stenosis.

The serum immunoreactive gastrin (IRG) level in infants with confirmed idiopathic hypertrophic pyloric stenosis (IHPS) has been determined and compared to that found in vomiting infants without IHPS, in normal infants, and in normal adults. The mean serum IRG level of normal infants (103 +/- 9 pg/ml (mean +/- SEM) exceeded that of normal adults (28 +/- 5 pg/ml). The preoperative mean serum IRG ...

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Serum gastrin levels have been studied in 70 patients with chronically reduced glomerular filtration rate (GFR) as estimated by 51Cr-EDTA clearance, creatinine, and beta2-microglobulin values. A strong dependence upon GFR was found, although the correlation between gastrin levels and GFR was not as high as that between beta2-microglobulin and GFR, indicating the existence of extrarenal factors ...

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Gel filtration studies on immunoreactive gastrin in serum from Zollinger-Ellison patients.

Sera from 15 patients with the Zollinger-Ellison syndrome were subjected to gel filtration on Sephadex G-50 superfine columns (10 x 2000 mm). The concentration of gastrin in the effluent was determined by a sensitive radioimmunoassay. Immunoreactive gastrin was eluted in four components in 14 sera. (1) Component I, eluted in the same position as proinsulin, constituted 9.7 +/- 1.2 (mean +/- SEM...

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Quantitative distribution of gastrin-like immunoreactive peptide in brain [proceedings].

Itaya, K. Br Ui, M. (1965)J. Lipid Res. 6, 16-20 Laurell, S. & Tibbling, G. (1967) Clin. Chim. Acta 16,57-62 Rodbell, M. (l964)J. Biol. Chem. 239,375-380 Silman, R. E., Chard, T., Landon, J., Lowry, P. J., Smith, I. & Young, I. M. (1977)Front. Horm. Res. 4, 179-187 Silman, R. E., Holland, D., Chard, T., Lowry, P. J., Hope, J., Rees, L. H., Thomas, A. & Nathanielsz, P. (1979)J. Endocrinol. 81,19-34

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ژورنال

عنوان ژورنال: Gut

سال: 1974

ISSN: 0017-5749

DOI: 10.1136/gut.15.2.102